If you suppress the hormone insulin, it tends to cause a diuretic effect, which some people like because it’s a weight loss, but you are losing some water, carbohydrate stores. Carbohydrates retain water, so you’re kind of losing that too. But your blood pressure goes down and it has a natriuretic effect, which means you’re excreting more sodium and that’s part of suppressing the insulin signalling pathway. And at 0.5 millimolar, that’s actually… that’s starting to become a significant amount of energy in the blood, you know, that your brain can use.
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