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Trimegestone, also given as 21(S)-hydroxy-17α,21-ethane-δ9-19-norprogesterone or as 21(S)-hydroxy-17α,21-dimethyl-19-norpregna-4,9-dien-3,20-dione, is a synthetic norpregnane steroid and a derivative of progesterone. It is specifically a confederated derivate of 17α-methylprogesterone and 19-norprogesterone, or of 17α-methyl-19-norprogesterone. Related derivatives of 17α-methyl-19-norprogesterone include demegestone and promegestone.
Pregnancy Trimethoprim and sulfamethoxazole cross the afterbirth and their safety in pregnant women has not been established. Case-guide studies have shown that there may be an union between exposure to folate antagonistic muscles and descent fault in humans. Trimethoprim is a folate counteracting and, in animalistic studies, both agents have been shown to motive foetal abnormalities (see portion 5.3).